2022-07-01 17:46


Conference: Bucharest University Faculty of Physics 2019 Meeting

Section: Polymer Physics

In vitro toxicity of novel iron oxide nanoparticles functionalized with polyvinyl alcohol (FexOy-APV)

Simona Liliana ICONARU(1), Mikael MOTELICA(2), Regis GUEGAN(3), Monica Luminita BADEA(4), Gabriel PREDOI(5), Stefania Mariana RAITA(5), Ana Maria ENE(1), Liliana GHEGOIU(1), Daniela PREDOI(1)

1) National Institute of Materials Physics, 405A Atomistilor Street, Magurele, Romania

2) ISTO, UMR 7327, CNRS, Université d’Orléans, 1A rue de la Férollerie, 45071 Orléans Cedex 2, France.

3) Faculty of Science and Engineering, Global Center for Science and Engineering, Waseda University, 3-4-1, Okubo, Shinjuku-ku, Tokyo 169-8555, Japan

4) University of Agronomic Sciences and Veterinary Medicine, 59 Mărăşti Blvd., 011464, Bucharest, Romania

5) Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 105 Splaiul Independentei, Sector 5, 050097 Bucharest, Romania


iron oxide, APV, in vitro, cytotoxicity

Nowadays, the rapid progress registered in the area of materials science and engineering has created outstanding opportunities for modern medicine by generate the premises of developing new and enhanced materials with impressive properties. Recently, tremendous efforts were made in the area of engineered particles to find an efficient route of synthesis for obtaining nanoparticles functionalized with biocompatible polymers. One of the most studies inorganic materials for their distinguished properties are iron oxide nanoparticles. This study reports the synthesis by and adapted coprecipitation method, and the characterization of novel iron oxide nanoparticles functionalized with polyvinyl alcohol (FexOy-APV) for biomedical applications. The structure and morphology of the obtained nanopowders were investigated by X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). The results indicated that the FexOy-APV nanoparticles presented a homogenous spherical morphology. Furthermore, the in vitro evaluation regarding the cytotoxicity of the samples illustrated that the particles do not exhibit any toxicity against the tested HeLa cells. The results obtained in this study revealed that the obtained iron oxide nanoparticles functionalized with polyvinyl alcohol (FexOy-APV) making them suitable for being used in biomedical applications.

This work was supported by the Romanian Ministry of Research and Innovation through the project PN-III-P1-1.2-PCCDI-2017-0134, Contract Nr. 23PCCDI/2018.