UNIVERSITY OF BUCHAREST
FACULTY OF PHYSICS

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2022-07-01 17:24

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Conference: Bucharest University Faculty of Physics 2019 Meeting


Section: Biophysics; Medical Physics


Title:
The synthesis of iron based magnetic nanoparticles for hyperthermia


Authors:
Luiza-Izabela JINGA (1), Gianina POPESCU-PELIN (1), Cristian MIHAILESCU (1), Livia SIMA (2), Gabriel SOCOL (1)


*
Affiliation:
1 National Institute for Lasers, Plasma and Radiation Physics, Bucharest-Magurele, Romania

2 Institute of Biochemistry of the Romanian Academy, Bucharest, Romania



E-mail
izabela.jinga@inflpr.ro


Keywords:
Hyperthermia, SPION, surface modification, silica coating, particle size


Abstract:
Superparamagnetic nanoparticles (SPION) have various applications in a large number of biomedical fields, such us hyperthermia, imaging diagnosis, biosensors and drug delivery [1]. Nowadays, magnetic hyperthermia has attracted significant attention as an alternative method for cancer therapy. The heat generated by magnetic nanoparticles in the presence of RF magnetic field can increase the temperature in tumors in a controlled manner, leading to killing the tumor cells with minimum damage of the normal ones [2]. The surface modification of SPION plays an important role in the interaction between nanoparticles and biological systems. In this context, silica coating, not only enhances colloidal stability, but also makes nanoparticles more biocompatible [3]. In this work, we report the synthesis of superparamagnetic nanoparticles with different particle size and surface modification, as well as their influence in the hyperthermia study. Based on the obtained results, new perspectives on development of new biocompatible and biofunctional SPION NPs for magnetic hyperthermia are highlited


References:

[1] K. C. Barick et al., AIP Publishing, 1942, (2018), 040020-1:040020-4.

[2] M. Doi et al., Materials Science and Engineering,30, (2016), 881:887.

[3] A. C. Samia et al., Progress in Natural Science: Materials International, 26, (2016), 440:448.



Acknowledgement:
This work was financially supported by The Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI), Project No.63 PCCDI/2018 (PN-III-P1-1.2-PCCDI-2017-0728).